BI-2493 | pan-KRAS inhibitor | Probechem Biochemicals

Chemical Structure : BI-2493

CAS No.: 2937344-16-4

加入收藏

BI-2493 (BI 2493)

货号: PC-20878Not For Human Use, Lab Use Only.

BI-2493 is a structural analogue of BI-2865 for in vivo administration, BI-2493 a potent, inactive state selective, non-covalent pan KRAS inhibitor.

规格	价格	库存
2 mg	￥2880	In stock
5 mg	￥4880	In stock
10 mg	￥7580	In stock
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BI-2493 is a structural analogue of BI-2865 for in vivo administration, BI-2493 a potent, inactive state selective, non-covalent pan KRAS inhibitor.
BI-2493 is highly selective for KRAS and does not cause more than 30% inhibition in a panel of 404 kinases or 38 targets commonly used in safety profiling .
BI-2493 attenuates tumour growth in mice bearing KRAS G12C, G12D, G12V and A146V mutant models, without causing apparent toxicity to the mice, shows inhibition of ERK phosphorylation and DUSP6 messenger RNA expression in tumour models.

物理化学性质&存储条件

分子量	461.59
分子式	C24H27N7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-3'-(2-((S)-2-methylpiperazin-1-yl)pyrimidin-4-yl)-5',6,6',7-tetrahydro-4'H,5H-spiro[benzo[b]thiophene-4,7'-benzo[d]isoxazole]-3-carbonitrile

参考文献

1. Dongsung Kim, et al. Nature. 2023 May 31. doi: 10.1038/s41586-023-06123-3.

BI-2493 (BI 2493)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BI-2493 (BI 2493)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.