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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-ACA-14
ACA-14

Chemical Structure : ACA-14

CAS No.:

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ACA-14 (ACA14)

货号: PC-20692Not For Human Use, Lab Use Only.

ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
ACA-14 inhibits signal transduction through the MAPK pathway in cells expressing mutant KRAS and inhibits the growth of pancreatic and colon cancer cells harboring mutant KRAS.

物理化学性质&存储条件

分子量 297.31
分子式 C17H15NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)C1=CC(NC(C2C(C3=CC=CC=C3)C2)=O)=CC=C1O

参考文献

1. Cynthia V Pagba, et al. ACS Bio Med Chem Au. 2022 Sep 26;2(6):617-626.

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