| Cat. No. |
Product Name |
Information |
| PC-61154 |
Deltasonamide 2
PDE6δ/KRas inhibitor
|
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM. |
| PC-61153 |
Deltasonamide 1
PDE6D-RAS inhibitor
|
Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM. |
| PC-61152 |
Deltazinone 1
PDE6D-RAS inhibitor
|
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
| PC-60886 |
UC-857993
SOS1-Ras inhibitor
|
UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
| PC-60885 |
UC-773587
SOS1-Ras inhibitor
|
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
| PC-70154 |
ML162
GPX4 inhibitor
|
ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-28259 |
GFH375
KRAS G12D inhibitor
|
GFH375 (VS-7375) is an orally bioavailable, noncovalent, selective KRAS G12D inhibitor, targets both 'ON' (GTP-bound) and 'OFF' (GDP-bound) states of KRASG12D proteins. |
| PC-27893 |
SCH51344
Ras/Rac inhibitor, MTH1 inhibitor
|
SCH51344 (SCH 51344) is a potent inhibitor of RAS transformation, specifically blocks membrane ruffling induced by activated forms of H-RAS, K-RAS, N-RAS and RAC, also potently inhibits MTH1 (NUDT1) with IC50 of 215 nM, 410 nM, and 675 nM for MTH1 substrates dGTP, 8-oxo-dGTP, and 2-OH-dATP. |
| PC-27417 |
Debecarasib
KRAS G12D inhibitor
|
Debecarasib is a potent and orally bioavailable inhibitor of GDP-bound KRAS G12D, shows highly selectivity for KRAS G12D against wild-type KRAS and other RAS mutations or amplifications. |
