UC-773587 |CAS:116679-69-7 Probechem Biochemicals

Chemical Structure : UC-773587

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UC-773587 (UC 773587;UC773587)

货号: PC-60885Not For Human Use, Lab Use Only.

UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.

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生物&药学活性

UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.
UC-773587 dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay.
UC-773587 dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling.
UC-773587 specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts.
UC-773587 inhibits Ras signaling and growth of pancreatic and prostate cancer cells.

物理化学性质&存储条件

分子量	432.431
分子式	C28H16O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid

参考文献

1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98.

UC-773587 (UC 773587;UC773587)

生物&药学活性

物理化学性质&存储条件

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UC-773587 (UC 773587;UC773587)

生物&药学活性

物理化学性质&存储条件

参考文献

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