ARS-853 (ARS853) | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : ARS-853

CAS No.: 1629268-00-3

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ARS-853 (ARS853, ARS 853)

货号: PC-45673Not For Human Use, Lab Use Only.

ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM.

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5 mg	￥2280	In stock
10 mg	￥3580	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM.
ARS-853 engages KRASG12C in biochemical assay with a rate constant of 76 M-1s-1, > 600-fold improvement compared with Compound 12 (Ostrem JM, Nature 2013;503:548–51.).
ARS-853 inhibits growth of H358 cells.
ARS-853 is the first direct KRAS inhibitor shown to selectively inhibit KRAS in cells with potency in the range of a drug candidate.

物理化学性质&存储条件

分子量	432.9437
分子式	C22H29ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 71 mg/mL
Chemical Name/SMILES	2-Propen-1-one, 1-[3-[4-[2-[[4-chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]-

参考文献

1. Patricelli MP, et al. Cancer Discov. 2016 Mar;6(3):316-29.

2. Lito P, et al. Science. 2016 Feb 5;351(6273):604-8.

ARS-853 (ARS853, ARS 853)

生物&药学活性

物理化学性质&存储条件

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ARS-853 (ARS853, ARS 853)

生物&药学活性

物理化学性质&存储条件

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