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1-AM

Chemical Structure : 1-AM

CAS No.:

1-AM (KRAS G12C inhibitor 1_AM, 1_AM)

货号: PC-61202Not For Human Use, Lab Use Only.

1-AM (1_AM) is a potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    1-AM (1_AM) is a potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.

    物理化学性质&存储条件

    分子量 510.998
    分子式 C26H28ClFN6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-((4-(4-acryloylpiperazin-1-yl)-6-chloro-7-(2-fluorophenyl)quinazolin-2-yl)amino)-N,N-dimethylpropanamide

    参考文献

    1. Zeng M, et al. Cell Chem Biol. 2017 Aug 17;24(8):1005-1016.e3.

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