ML162 | GPX4 inhibitor | ProbeChem Biochemicals

Chemical Structure : ML162

CAS No.: 1035072-16-2

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ML162 (ML 162, ML-162)

货号: PC-70154Not For Human Use, Lab Use Only.

ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5280	In stock
250 mg		Get quote

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生物&药学活性

ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
ML162 displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines.
ML162 is a useful tool for identifying oncogene-specific pathways and targets in cancer cells.

物理化学性质&存储条件

分子量	477.4
分子式	C23H22CI2N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide

参考文献

1. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.

2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML162 (ML 162, ML-162)

生物&药学活性

物理化学性质&存储条件

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ML162 (ML 162, ML-162)

生物&药学活性

物理化学性质&存储条件

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