UC-857993 |CAS:487001-04-7 Probechem Biochemicals

Chemical Structure : UC-857993

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UC-857993 (UC 857993;UC857993)

货号: PC-60886Not For Human Use, Lab Use Only.

UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction.
UC-857993 dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay.
UC-857993 dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling.
UC-857993 specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts.
UC-857993 inhibits Ras signaling and growth of pancreatic and prostate cancer cells.

物理化学性质&存储条件

分子量	403.906
分子式	C25H22ClNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-chlorophenyl)-3b,6,6a,7,9,9a,10,12a-octahydrocyclopenta[4,5]pyrido[3,2,1-ij]cyclopenta[c]quinoline-2-carboxylic acid

参考文献

1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98.

UC-857993 (UC 857993;UC857993)

生物&药学活性

物理化学性质&存储条件

参考文献

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UC-857993 (UC 857993;UC857993)

生物&药学活性

物理化学性质&存储条件

参考文献

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