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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-Deltasonamide 1
Deltasonamide 1

Chemical Structure : Deltasonamide 1

CAS No.: 2088485-33-8

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Deltasonamide 1 (Deltasonamide1)

货号: PC-61153Not For Human Use, Lab Use Only.

Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM.
PDE6δ/KRas inhibits PDE6δ/KRas interaction in cells with Kd of 85 nM.
PDE6δ/KRas selectively inhibits growth of KRas mutated and -dependent cells.

物理化学性质&存储条件

分子量 647.25
分子式 C30H39ClN6O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1-(4-chlorobenzyl)-N1-cyclopentyl-N4-((2-(methylamino)pyrimidin-4-yl)methyl)-N4-(piperidin-4-ylmethyl)benzene-1,4-disulfonamide

参考文献

1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.

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