| Cat. No. |
Product Name |
Information |
| PC-25973 |
RNK08954
KRAS G12D inhibitor
|
RNK08954 is a potent, selective, non-covalent and orally bioavailable KRAS G12D inhibitor, binds primarily to the inactive KRAS G12D (GDP-bound) with SPR KD of 39.5 pM and to the active KRAS G12D (GTP-bound) form with KD of 12.2 nM. |
| PC-25958 |
Deltafluorine
PDEδ inhibitor
|
Deltafluorine is a specific small molecule PDEδ inhibitor with ITC KD of 148 nM and binding IC50 of 25 nM, targeting the binding site glutamate p.E88 in PDEδ, impairs K-Ras signaling. |
| PC-25585 |
C4-180
RALGEF inhibitor
|
C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS. |
| PC-25265 |
MCB-294
KRAS inhibitor
|
MCB-294 is a potent, selective, dual-state pan-KRAS inhibitor capable of binding both the active (GTP-bound) and inactive (GDP-bound) forms of KRAS, effectively inactivates both wild-type KRAS and multiple KRAS mutants. |
| PC-24662 |
AMG410
KRAS inhibitor
|
AMG410 is a potent, non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D,> 100-fold selectivity against both HRAS and NRAS. |
| PC-24126 |
D3S-001
KRAS G12C inhibitor
|
Elisrasib (D3S-001) is a potent, selective, CNS-penetrable, covalent inhibitor of GDP-bound KRAS G12C inhibitor, decreases cellular active KRAS proteins in a dose-dependent manner (IC50=0.6 nM) in NCI-H358 cells. |
| PC-23832 |
RMC-9805
KRAS G12D inhibitor
|
Zoldonrasib (RMC-9805) is a potent, selective and covalent inhibitor of KRAS G12D with EC50 of 23 nM (AsPC-1, pERK), highly selective for crosslinking RAS G12D(ON). |
| PC-23212 |
ADT-1004
Ras inhibitor
|
ADT-1004 is an orally bioavailable prodrug of ADT-007, potent, selective pan-RAS inhibitor, selectively inhibits PDAC cells with mutant KRAS, does not impact the growth of tumors from RAS WT PDAC cells. |
| PC-22982 |
Sotorasib
KRAS G12C inhibitor
|
Sotorasib (AMG-510) is a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM. |
| PC-22872 |
KRAS G12C inhibitor 143D
KRAS G12C inhibitor
|
143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM. |
| PC-22804 |
RGT-018
SOS1 inhibitor
|
RGT-018 (RGT018) is a potent and selective SOS1 inhibitor, blocks interaction of KRAS:SOS1 with single digit nM potency and is highly selective against SOS2. |
| PC-22656 |
HRS-4642
KRAS G12D inhibitor
|
HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor with SPR KD of 0.083 nM, >20-fold selective over wild-type KRAS and KRAS G12C. |
