KRAS G12C inhibitor 143D | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : KRAS G12C inhibitor 143D

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KRAS G12C inhibitor 143D (143D)

货号: PC-22872Not For Human Use, Lab Use Only.

143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM.

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生物&药学活性

143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM.
143D shows little effect on the binding of KRASG12D and SOS1.
143D displays potent antiproliferative activity by causing cell cycle arrest and apoptosis, shows significant antiproliferative effects on the KRASG12C-transformed Ba/F3 cell line with IC50 of 10 nM.
143D selectively inhibits the constitutive activation of KRASG12C signaling pathways.
143D inhibits the KRAS signaling pathway and growth of KRASG12C-mutant tumors.

物理化学性质&存储条件

分子量	629.18
分子式	C35H38ClFN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-(7-(8-chloronaphthalen-1-yl)-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5,6,7,8-tetrahydro-1,7-naphthyridin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

参考文献

1. Xu LS, et al. Acta Pharmacol Sin. 2023 Jul;44(7):1475-1486.

KRAS G12C inhibitor 143D (143D)

生物&药学活性

物理化学性质&存储条件

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KRAS G12C inhibitor 143D (143D)

生物&药学活性

物理化学性质&存储条件

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