| Cat. No. |
Product Name |
Information |
| PC-36062 |
ZT-12-037-01
STK19 inhibitor
|
ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation. |
| PC-36032 |
(S)-BAY-293
|
(S)-BAY-293 (BAY293 S-enantiomer) is the S-enantiomer of BAY-293 as a negative control compound.. |
| PC-36031 |
BAY-293 racemate
SOS1 inhibitor
|
BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM). |
| PC-36030 |
BAY-293
SOS1 inhibitor
|
BAY-293 (BAY293, BAY 293) is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. |
| PC-35953 |
KRAS G12C inhibitor 11
KRAS G12C inhibitor
|
KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM. |
| PC-35952 |
MRTX1257
KRAS G12C inhibitor
|
MRTX1257 (MRTX-1257, MRTX 1257) is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM. |
| PC-35921 |
RAS activator compound 1
RAS activator
|
RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM. |
| PC-35878 |
KRAS G12C inhibitor 13
KRAS G12C inhibitor
|
KRAS G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays. |
| PC-35765 |
KRAS4b-PDEδ stablizer C19
PDE6D-RAS stablizer
|
KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells. |
| PC-35613 |
KBFM123
H-Ras inhibitor
|
KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM). |
| PC-35594 |
KRAS G12V inhibitor C6ME
KRAS G12V inhibitor
|
KRAS G12V inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro. |
| PC-35593 |
KRAS G12V inhibitor Cmpd2
KRAS G12V inhibitor
|
KRAS G12V inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro. |
