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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-AZD4625
AZD4625

Chemical Structure : AZD4625

CAS No.: 2387927-95-7

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AZD4625 (AZD-4625)

货号: PC-38549Not For Human Use, Lab Use Only.

AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.

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5 mg ￥8980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.
AZD4625 is a clinical development candidate for the treatment of KRASG12C positive tumors.

物理化学性质&存储条件

分子量 486.904
分子式 C24H21ClF2N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((3R,14aS)-11-chloro-9-fluoro-10-(2-fluoro-6-hydroxyphenyl)-3-methyl-1,3,4,13,14,14a-hexahydro-2H-pyrazino[1',2':5,6][1,5]oxazocino[4,3,2-de]quinazolin-2-yl)prop-2-en-1-one

参考文献

1. Jason G. Kettle, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.2c00369

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