TH-Z835 | KRAS G12D inhibitor | Probechem Biochemicals

Chemical Structure : TH-Z835

CAS No.: 2766209-50-9

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TH-Z835 (THZ 835)

货号: PC-73005Not For Human Use, Lab Use Only.

TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM.

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1 mg	￥2880	In stock
5 mg	￥4980	In stock
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生物&药学活性

TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM.
TH-Z835 binds to both GDP-bound and GMPPNP-bound KRAS G12D with similar affinities, efficiently disrupt KRAS–CRAF interaction, but do not bind to wide type and G12C mutant KRAS.
TH-Z835 reduced the pERK level in PANC-1 cells with an IC50 <2.5 uM, exhibited anti-proliferative effects for KRAS(G12D)-bearing pancreatic cancer cell lines PANC-1 and KPC with IC50 of <0.5 uM, induced arrest at the G1 phase of the cell cycle.
TH-Z835 displayed anti-tumor effects alone and in combination with anti-PD-L1 antibody in xenograft pancreatic tumor models.

物理化学性质&存储条件

分子量	498.675
分子式	C30H38N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,8-Diazabicyclo[3.2.1]octane, 3-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-

参考文献

1. Mao Z, et al. Cell Discov. 2022 Jan 25;8(1):5.

TH-Z835 (THZ 835)

生物&药学活性

物理化学性质&存储条件

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TH-Z835 (THZ 835)

生物&药学活性

物理化学性质&存储条件

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