Garsorasib (D-1553) | KRas-G12C inhibitor | Probechem Biochemicals

Chemical Structure : Garsorasib

CAS No.: 2559761-14-5

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Garsorasib (D-1553, D1553)

货号: PC-73419Not For Human Use, Lab Use Only.

Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines.
Garsorasib (D-1553) shows specific activity in cancer cells with KRas-G12C mutation, including lung, pancreatic and colorectal cancers.
Garsorasib (D-1553) is highly potent in vivo in various cell line-derived xenograft tumor models with KRas-G12C mutation as a single agent.
Garsorasib (D-1553) demonstrates further tumor growth inhibition or regression in tumor xenograft models, when combined with MEK inhibitor, SHP2 inhibitor or cytotoxic agents.
Garsorasib (D-1553) has anti-tumor activity in a broad spectrum of cancers and is suitable for tissue-agnostic clinical development targeting cancers with KRas-G12C mutation.

物理化学性质&存储条件

分子量	598.659
分子式	C32H32F2N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-amino-6-fluorophenyl)-1-(4,6- dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethyl-4- (prop-2-enoyl)piperazin-1-yl]-6-fluoropyrido[2,3- d]pyrimidin-2(1H)-one

参考文献

1. Albert K Kwan, et al. J Exp Clin Cancer Res. 2022 Jan 19;41(1):27.

2. Zhe Shi, et al. Cancer Res (2021) 81 (13_Supplement): 932.

Garsorasib (D-1553, D1553)

生物&药学活性

物理化学性质&存储条件

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Garsorasib (D-1553, D1553)

生物&药学活性

物理化学性质&存储条件

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