| Cat. No. |
Product Name |
Information |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-26521 |
SOS1 inhibitor SL43
SOS1 inhibitor
|
SOS1 inhibitor SL43 is a potent, selective and orally bioavailable SOS1 inhibitor with binding KD of 0.16 uM, potently disrupts the SOS1-KRASG12C interaction with IC50 of 13 nM, broadly inhibits SOS1-mediated nucleotide exchange on multiple KRAS mutants (G12C, G12V and G12D; IC50 = 13.4-29.1 nM). |
| PC-26456 |
DJX-A-KM
KRASG12C degrader
|
DJX-A-KM is a potent, selective FBXO28-recruiting degrader of KRASG12C with DC50 of 2 nM in NCI-H23 cells, Dmax=98%. |
| PC-26395 |
XMU-MP-9
K-RAS mutants degrader
|
XMU-MP-9 is bifunctional, specific small molecule K-RAS mutants degrader, facilitates NEDD4-1-mediated ubiquitination and degradation of various oncogenic K-RAS mutants. |
| PC-26309 |
BI-1830
KRAS G12D inhibitor
|
BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells. |
| PC-26225 |
BBO-11818
KRAS inhibitor
|
BBO-11818 is a potent, selective, orally bioavailable noncovalent pan-KRAS inhibitor, potently disrupts the interaction of RAF1-RAS Binding Domain (RBD) with KRASG12D (IC50=28 nM), KRASG12V (IC50=61 nM), KRASG12C (IC50=47 nM), and KRASG12R (IC50=51 nM), as well as KRASWT (IC50=120 nM). |
| PC-26023 |
Dual SLC25A51 and SDHA inhibitor 615
SLC25A51/SDHA inhibitor
|
Dual SLC25A51 and SDHA inhibitor 615 is a specific small molecule dual inhibitor of SLC25A51 and succinate dehydrogenase (SDH) subunit SDHA, selectively kills KRAS-mutated cells. |
| PC-25991 |
KRAS G12C inhibitor compound 8
KRAS G12C inhibitor
|
KRAS G12C inhibitor compound 8 is a potent, specific KRAS G12C dual inhibitor with IC50 of 10 nM (GDP Exchange Inhibition) and 133 nM (RAS/RAF Disruption), covalently modifies both KRAS G12C inactive and active states. |
| PC-25960 |
PDE6δ-IN-2
PDEδ inhibitor
|
PDE6δ-IN-2 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
| PC-25959 |
PDE6δ-IN-1
PDEδ inhibitor
|
PDE6δ-IN-1 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
