| Cat. No. |
Product Name |
Information |
| PC-61154 |
Deltasonamide 2
PDE6δ/KRas inhibitor
|
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM. |
| PC-61153 |
Deltasonamide 1
PDE6D-RAS inhibitor
|
Deltasonamide 1 is a specific small molecule inhibitor of PDE6δ/KRas interaction with Kd of 203 pM. |
| PC-61152 |
Deltazinone 1
PDE6D-RAS inhibitor
|
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
| PC-60886 |
UC-857993
SOS1-Ras inhibitor
|
UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
| PC-60885 |
UC-773587
SOS1-Ras inhibitor
|
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
| PC-70154 |
ML162
GPX4 inhibitor
|
ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-27036 |
JMKX1899
KRAS G12C inhibitor
|
JMKX1899 is a potent and selective, covalent, BBB-penetrating KRAS G12C inhibitor. |
| PC-26521 |
SOS1 inhibitor SL43
SOS1 inhibitor
|
SOS1 inhibitor SL43 is a potent, selective and orally bioavailable SOS1 inhibitor with binding KD of 0.16 uM, potently disrupts the SOS1-KRASG12C interaction with IC50 of 13 nM, broadly inhibits SOS1-mediated nucleotide exchange on multiple KRAS mutants (G12C, G12V and G12D; IC50 = 13.4-29.1 nM). |
| PC-26395 |
XMU-MP-9
K-RAS mutants degrader
|
XMU-MP-9 is bifunctional, specific small molecule K-RAS mutants degrader, facilitates NEDD4-1-mediated ubiquitination and degradation of various oncogenic K-RAS mutants. |
