| Cat. No. |
Product Name |
Information |
| PC-22365 |
Deltaflexin3
PDE6D inhibitor
|
Deltaflexin3 is a highly potent, selective and highly soluble inhibitor of the trafficking chaperone PDE6D (PDEδ) with KD value of 6 nM, inhibits PDE6D/K-Ras binding and KRAS mutant cancer cell growth. |
| PC-22125 |
RMC-6236
Ras inhibitor
|
RMC-6236 is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants. |
| PC-22123 |
BBO-8520
KRAS G12C inhibitor
|
BBO-8520 is a potent, selective and covalent inhibitor of KRAS G12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding. |
| PC-22112 |
RMC-7977
Ras inhibitor
|
RMC-7977 is a potent, highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with Kd of 116 nM, 94.7 nM and 101 nM respectively, KRAS G12V Kd of 85 nM. |
| PC-21798 |
SIJ1772
mutated RAS inhibitor
|
SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively. |
| PC-21797 |
SIJ1795
mutated RAS inhibitor
|
SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively. |
| PC-21686 |
BBO-8956
KRAS G12C inhibitor
|
BBO-8956 is a highly potent, covalent inhibitor of GTP-KRAS G12C, BBO-8956 is effective against both GDP and GTP-bound KRAS G12C. |
| PC-21640 |
ASP6918
KRAS G12C inhibitor
|
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells. |
| PC-21604 |
Kobe2602
Ras inhibitor
|
Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM. |
| PC-21544 |
KRAS G13D inhibitor 41
KRAS G13D inhibitor
|
KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS. |
| PC-21543 |
K-Ras G12C inhibitor 6
KRAS G12C inhibitor
|
K-Ras(G12C) inhibitor 6 is a potent, irreversible, allosteric inhibitor of the K-Ras(G12C). |
| PC-21375 |
AVJ16
Igf2bp1 inhibitor
|
AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays. |
