pan-Ras inhibitor 3144 |CAS:1835283-94-7 Probechem Biochemicals

Chemical Structure : pan-Ras inhibitor 3144

CAS No.: 1835283-94-7

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pan-Ras inhibitor 3144 (Compound 3144)

货号: PC-62695Not For Human Use, Lab Use Only.

pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively.
pan-Ras inhibitor 3144 shows weak bindinf for RRAS2 (Kd=24 uM) and no activity for other small GTPases in the RAS superfamily.
pan-Ras inhibitor 3144 exhibits lethality in cells partially dependent on expression of RAS proteins.
pan-Ras inhibitor 3144 has suitable ADME properties and displays anti-tumor activity in xenograft mouse of pancreatic cancer; orally bioavailable.

物理化学性质&存储条件

分子量	717.659
分子式	C36H41Cl2F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-N-(3-(5-((4-(2,6-dichlorobenzyl)piperazin-1-yl)methyl)-3-(4-(trifluoromethoxy)phenyl)-1H-indol-1-yl)propyl)piperidine-4-carboxamide

参考文献

1. Welsch ME, et al. Cell. 2017 Feb 23;168(5):878-889.e29.

pan-Ras inhibitor 3144 (Compound 3144)

生物&药学活性

物理化学性质&存储条件

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pan-Ras inhibitor 3144 (Compound 3144)

生物&药学活性

物理化学性质&存储条件

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