RasGRP3 ligand 96 |CAS:2229068-13-5 Probechem Biochemicals

Chemical Structure : RasGRP3 ligand 96

CAS No.: 2229068-13-5

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RasGRP3 ligand 96

货号: PC-35300Not For Human Use, Lab Use Only.

RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively.

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5 mg	￥8580	In stock
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生物&药学活性

RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, shows 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively.
RasGRP3 ligand 96 induces Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation in intact cells.

物理化学性质&存储条件

分子量	371.433
分子式	C21H25NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-(2-(Hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate

参考文献

1. Ann J, et al. J Med Chem. 2018 Jul 3. doi: 10.1021/acs.jmedchem.8b00661.

RasGRP3 ligand 96

生物&药学活性

物理化学性质&存储条件

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RasGRP3 ligand 96

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物理化学性质&存储条件

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