NSC 658497 |CAS:909197-38-2 Probechem Biochemicals

Chemical Structure : NSC 658497

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NSC 658497 (NSC658497)

货号: PC-62490Not For Human Use, Lab Use Only.

NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.

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生物&药学活性

NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.
NSC 658497 showes dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation.

物理化学性质&存储条件

分子量	438.428
分子式	C20H10N2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(((Z)-5-(4-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)methylene)chroman-2,4-dione

参考文献

1. Evelyn CR, et al. Chem Biol. 2014 Dec 18;21(12):1618-28.

NSC 658497 (NSC658497)

生物&药学活性

物理化学性质&存储条件

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NSC 658497 (NSC658497)

生物&药学活性

物理化学性质&存储条件

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