Kobe0065 | Ras inhibitor | Probechem Biochemicals

Chemical Structure : Kobe0065

CAS No.: 436133-68-5

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Kobe0065 (Kobe 0065)

货号: PC-38456Not For Human Use, Lab Use Only.

Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM.

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10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

Kobe0065 is a small-molecule Ras inhibitor, competitively inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 46 uM.
Kobe0065 effectively inhibit both anchorage-dependent and -independent growth and induce apoptosis of H-rasG12V–transformed NIH 3T3 cells (IC50=0.5 uM).
Kobe0065 exhibit antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.

物理化学性质&存储条件

分子量	449.79
分子式	C15H11ClF3N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide

参考文献

1. Shima F, et al. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.

2. Shima F, et al. Enzymes. 2013;34 Pt. B:1-23.

3. Yoshikawa Y, et al. Cancer Lett. 2017 Dec 1;410:82-91.

Kobe0065 (Kobe 0065)

生物&药学活性

物理化学性质&存储条件

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Kobe0065 (Kobe 0065)

生物&药学活性

物理化学性质&存储条件

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