Chelidonine (Stylophorin) | STK19 inhibitor | Probechem Biochemicals

Chemical Structure : Chelidonine

CAS No.: 476-32-4

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Chelidonine (Stylophorin, (+)-Chelidonine)

货号: PC-72222Not For Human Use, Lab Use Only.

Chelidonine (Stylophorin, (+)-Chelidonine) is a potent, selective, ATP-competitive inhibitor of STK19 kinase activity, inhibits STK19-mediated NRAS S89 phosphorylation with IC50 of 125 nM, inhibits NRAS-mediated signaling.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
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生物&药学活性

Chelidonine (Stylophorin, (+)-Chelidonine) is a potent, selective, ATP-competitive inhibitor of STK19 kinase activity, inhibits STK19-mediated NRAS S89 phosphorylation with IC50 of 125 nM, inhibits NRAS-mediated signaling.
In vitro, Chelidonine treatment inhibited NRAS signaling, leading to reduced cell proliferation and induction of apoptosis in a panel of NRAS-mutant cancer cell lines, including melanoma, liver, lung, and gastric cancer.
In vivo, Chelidonine suppressed the growth of NRAS-driven tumor cells in nude mice while exhibiting minimal toxicity.
Chelidonine is one of the most abundant bioactive isoquinoline alkaloids in extracts of the plant Chelidonium majus, which is also known as the greater celandine (Papaveraceae) and is widely distributed throughout Europe and Asia.
Chelidonine possess antitumor properties, including inhibition of cell proliferation, potentiation of apoptosis, and suppression of cell migration and invasion, in cell lines from such diverse cancers as uveal melanoma, head and neck cancer, gastric carcinoma, liver cancer, and breast cancer.

物理化学性质&存储条件

分子量	353.374
分子式	C20H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5bR,6S,12bS)-13-Methyl-5b,6,7,12b,13,14-hexahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol

参考文献

1. Ling Qian, et al. Clin Cancer Res. 2020 Jul 1;26(13):3408-3419.

Chelidonine (Stylophorin, (+)-Chelidonine)

生物&药学活性

物理化学性质&存储条件

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Chelidonine (Stylophorin, (+)-Chelidonine)

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