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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-NSC290956
NSC290956

Chemical Structure : NSC290956

CAS No.: 24527-27-3

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NSC290956 (Spiclomazine, Clospirazine)

货号: PC-72832Not For Human Use, Lab Use Only.

NSC290956 (Spiclomazine, Clospirazine) is a small molecule inhibitor of KRas with Kd of 21.3 uM.

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10 mg ￥1480 In stock
25 mg ￥2680 In stock
50 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC290956 (Spiclomazine, Clospirazine) is a small molecule inhibitor of KRas with Kd of 21.3 uM.
NSC290956 inhibits KRas activity and downstream signaling events in KRas-driven nuytant NSCLC cells, decreases the cellular viability, cell cycle, and migration.
NSC290956 changes KRas-dependent metabolic phenotype in Non-small-cell lung cancer cells, regulates mitochondrial dysfunction for apoptosis in both A549 and H358 cells.
NSC290956 shows activity in the KRas mutant cell line xenograft.

物理化学性质&存储条件

分子量 446.024
分子式 C22H24ClN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(3-(2-chloro-10h-phenothiazin-10-yl)propyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one

参考文献

1. Jiaxin Zhang, et al. Front Pharmacol. 2022 Jan 5;12:797821.

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