BAY-293 racemate |CAS:2244904-14-9 Probechem Biochemicals

Chemical Structure : BAY-293 racemate

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BAY-293 racemate (BAY293 racemate)

货号: PC-36031Not For Human Use, Lab Use Only.

BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).

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生物&药学活性

BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).

物理化学性质&存储条件

分子量	448.585
分子式	C25H28N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine

参考文献

1. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Jan 25. pii: 201812963. doi: 10.1073/pnas.1812963116.

BAY-293 racemate (BAY293 racemate)

生物&药学活性

物理化学性质&存储条件

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BAY-293 racemate (BAY293 racemate)

生物&药学活性

物理化学性质&存储条件

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