KRAS G12C inhibitor 13 |CAS:2158296-45-6 Probechem Biochemicals

Chemical Structure : KRAS G12C inhibitor 13

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KRAS G12C inhibitor 13

货号: PC-35878Not For Human Use, Lab Use Only.

KRAS G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays.

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250 mg		Get quote

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生物&药学活性

KRAS G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays.
KRAS-G12C inhibitor 13 displays no significant activity against non-G12C cell lines with IC50 of >16 uM.
KRAS-G12C inhibitor 13 demonstrates KRAS-G12C target engagement in vivo and antitumor efficacy in the MIA PaCa-2 tumor xenograft models.

物理化学性质&存储条件

分子量	528.657
分子式	C30H36N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-(7-(3-hydroxynaphthalen-1-yl)-2-((1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one

参考文献

1. Jay B. Fell, et al. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00382.