KRAS4b-PDEδ stablizer C19

Chemical Structure : KRAS4b-PDEδ stablizer C19

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货号: PC-35765Not For Human Use, Lab Use Only.

KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells。
KRAS4b-PDEδ stablizer C19 showed high cytotoxicity in the colorectal cancer cell lines HCT116 and LoVo, with a stronger effect in KRAS-dependent LoVo cells.
KRAS4b-PDEδ stablizer C19 significantly decreased tumor size in a xenograft mouse model and showed lower side effects than 5-FU.

物理化学性质&存储条件

分子量	385.285
分子式	C18H22Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-N-(2,5-dichlorophenyl)-2-(((3,4-dimethoxycyclohexa-2,5-dien-1-yl)methyl)amino)propanamide

参考文献

1. Cruz-Nova P, et al. BMC Cancer. 2018 Nov 1;18(1):1056.