KRAS G12V inhibitor Cmpd2

Chemical Structure : KRAS G12V inhibitor Cmpd2

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货号: PC-35593Not For Human Use, Lab Use Only.

KRAS G12V inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KRAS G12V inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
KRAS G12V inhibitor Cmpd2 inhibits cell proliferation in SW1990 cells with EC50 of 2.7 uM.
The potency of Cmpd2 was strongly enhanced when prenylated K-RAS4B is associated with a lipid bilayer.

物理化学性质&存储条件

分子量	446.773
分子式	C21H21BrClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-N-((2R,4S)-2-(4-chlorobenzyl)piperidin-4-yl)-1H-indole-3-carboxamide

参考文献

1. Fang Z, et al. Cell Chem Biol. 2018 Aug 14. pii: S2451-9456(18)30261-7.

2. Jansen JM, et al. PLoS One. 2017 Apr 6;12(4):e0174706.