KRAS G12C inhibitor 11 |CAS:2158297-63-1 Probechem Biochemicals

Chemical Structure : KRAS G12C inhibitor 11

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KRAS G12C inhibitor 11

货号: PC-35953Not For Human Use, Lab Use Only.

KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM.
KRAS G12C inhibitor 11 demonstrates super proportional dose ascending oral exposure in mice with 3h target coverage at the 30 mg/kg dose.
KRAS G12C inhibitor 11 shows rapid growth inhibition and durable efficacy even after dosing was stopped, orally active.

物理化学性质&存储条件

分子量	551.695
分子式	C32H37N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((S)-1-acryloyl-4-(2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile

参考文献

1. U.S. Pat. Appl. Publ. (2018), US 20180072723 A1 20180315.