RAS inhibitor Abd-7 |CAS 2351843-48-4 Probechem Biochemicals

Chemical Structure : RAS inhibitor Abd-7

CAS No.: 2351843-48-4

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RAS inhibitor Abd-7

货号: PC-35587Not For Human Use, Lab Use Only.

RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling.
RAS inhibitor Abd-7 impairs the protein-protein interaction (PPI) of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRASQ61H and HRASG12V.
RAS inhibitor Abd-7 inhibits phosphorylation of both downstream biomarkers in colorectal cancer (DLD-1, KRASG13D) and NSCLC (H538, KRASG12C) human cell lines, with reduction of AKT phosphorylation starting at 2 uM.
RAS inhibitor Abd-7 shows consistent inhibitory effects in the cell-based BRET assay and the biomarker assay.

物理化学性质&存储条件

分子量	391.471
分子式	C23H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-N-(4-((dimethylamino)methyl)phenyl)-2-methoxypyridin-3-amine

参考文献

1. Quevedo CE, et al. Nat Commun. 2018 Aug 9;9(1):3169.

RAS inhibitor Abd-7

生物&药学活性

物理化学性质&存储条件

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RAS inhibitor Abd-7

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物理化学性质&存储条件

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