| Cat. No. |
Product Name |
Information |
| PC-23575 |
Dipyridamole
PDE inhibitor, Ferroptosis inhibitor
|
Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor, also is a potent inhibitor of ferroptosis in pulmonary epithelial and endothelial cells, binds to and activates superoxide dismutase 1 (SOD1). |
| PC-23567 |
ENPP1 inhibitor VIR3
ENPP1 inhibitor
|
VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays. |
| PC-23488 |
PDE8 inhibitor 15
PDE8 inhibitor
|
PDE8 inhibitor 15 is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 11 nM (PDE8A), high selectivity over other PDEs. |
| PC-23487 |
PDE8A inhibitor 3a
PDE8 inhibitor
|
PDE8A inhibitor 3a is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 10 nM, >220-fold selective over PDE1B, PDE3A, PDE5A1, PDE7A1, PDE9A2, and PDE11A4. |
| PC-23485 |
VP1.15
PDE7/GSK-3 inhibitor
|
VP1.15 is a potent, dual PDE7/GSK-3 inhibitor with IC50 of 1.1 (PDE7) and 1.95 uM (GSK-3), shows antipsychotic and cognitive capacities. |
| PC-23482 |
BC11-38
PDE11 inhibitor
|
BC11-38 is a potent and selective PDE11 inhibitor with IC50 of 0.28 uM, without acitivity against PDE1-10. |
| PC-23481 |
BC8-15C
PDE11A inhibitor
|
BC8-15C is a potent, selective PDE11A inhibitor with IC50 of 0.08 uM in in vitro enzyme assays, also inhibits PDE4A with IC50 of 0.13 uM, shows little to no activity against PDE1, PDE2, PDE3, PDE5, PDE9, PDE10. |
| PC-23480 |
BC8-15
PDE4/PDE8 inhibitor
|
BC8-15 is a small molecule inhibitor of PDE4 and PDE8 with IC50 of 0.28 uM (PDE4A) and 0.22 uM (PDE8A), also displays significant activity against PDE10A and PDE11A (IC50=1.2-1.6 uM). |
| PC-23406 |
RF26
PDE5 inhibitor
|
RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes. |
| PC-23191 |
PDE11A4 inhibitor 14b
PDE11A4 inhibitor
|
SMQ-03-20 (PDE11A4 inhibitor 14b) is a potent, selective, brain-penetrant PDE11A4 inhibitor with IC50 of 53 nM, cAMP EC50 of 4.3 uM. |
| PC-21517 |
PDE4B inhibitor A-33
PDE4B inhibitor
|
PDE4B inhibitor A-33 is a potent, selective inhibitor of PDE4B with IC50 of 15 nM, >100-fold selective over PDE4D. |
| PC-21464 |
ME3183
PDE4 inhibitor
|
Morcamilast (ME3183) is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively. |
