ENPP1 inhibitor VIR3

Chemical Structure : ENPP1 inhibitor VIR3

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货号: PC-23567Not For Human Use, Lab Use Only.

VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

VIR3 is a potent, orally bioavailable Enpp1 with IC50 of <0.75 nM for ENPP1 cGAMP hydrolysis activity inhibition in in vitro assays.
VIR3 protect spiked-in cGAMP from hydrolysis overnight with an EC50 of 6.7 nM, in cellular assays using HepG2 cells that express ENPP1 on their surface.
VIR3 does not impact tumor growth alone, it significantly improved the response to radiation therapy in Enpp1-negative colorectal carcinoma models.

物理化学性质&存储条件

分子量	386.47
分子式	C19H22N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((R)-2-hydroxypropyl)-4-((7-methoxyquinolin-4-yl)amino)benzenesulfonimidamide

参考文献

1. Baird JR, et al. Sci Rep. 2024 Dec 2;14(1):29913.