PDE7A inhibitor 26

Chemical Structure : PDE7A inhibitor 26

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货号: PC-23896Not For Human Use, Lab Use Only.

PDE7A inhibitor 26 is a potent, selective PDE7A inhibitor with IC50 of 3.7 nM, 54-fold selective over PDE7B.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PDE7A inhibitor 26 is a potent, selective PDE7A inhibitor with IC50 of 3.7 nM, 54-fold selective over PDE7B.
PDE7A inhibitor 26 weakly inhibits PDE4D with IC50 of 1.6 uM.
PDE7A inhibitor 26 exhibits cell IC50 of 0.39 uM for ECR5 enhancer activity.
PDE7A inhibitor 26 is a useful probe to unveil new pharmacological roles of PDE7A-dependent signaling, as exemplified by the in vivo antiosteoporotic effects.

物理化学性质&存储条件

分子量	463.97
分子式	C25H26ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-chloro-6-cyclopropyl-3-ethyl-2-((1-(5-phenylpicolinoyl)pyrrolidin-3-yl)amino)pyrimidin-4(3H)-one

参考文献

1. Kondo K, et al. ACS Med Chem Lett. 2024 Dec 27;16(1):167-173.