| Cat. No. |
Product Name |
Information |
| PC-25004 |
OMS824
PDE10 inhibitor
|
OMS824 (OMS-824) is a potent, selective phosphodiesterase 10 (PDE10) inhibitor. |
| PC-25003 |
PDE10A inhibitor 3e
PDE10A inhibitor
|
PDE10A inhibitor 3e is a potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 6.5 nM, >95-fold selective over other PDEs. |
| PC-25002 |
Ibudilast
PDE inhibitor
|
Ibudilast (KC-404, AV-411, MN-166) is a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE) 3, PDE4, PDE10, and PDE11, shows platelet anti-aggregatory effects. |
| PC-24966 |
AWD 12-281
PDE4 inhibitor
|
AWD 12-281 (GW 842470) is a potent, orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 9.7 nM. |
| PC-24956 |
PF-07038124 hydrochloride
PDE4B2 inhibitor
|
Idrebormilast hydrochloride (PF-07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays. |
| PC-24217 |
TP-10
PDE10A inhibitor
|
TP-10 is a potent, selective inhibitor of cyclic nucleotide phosphodiesterase PDE10A with IC50 of 0.8 nM. |
| PC-23484 |
VP3.15 dihydrobromide
PDE7/GSK-3 inhibitor
|
VP3.15 dihydrobromide is a potent, oral bioavailable and CNS penetrant dual PDE7/GSK-3 inhibitor with IC50 of 1.59 uM (PDE7) and 0.88 uM (GSK-3). |
| PC-23410 |
PDE1 inhibitor 3f
PDE1 inhibitor
|
PDE1 inhibitor 3f is a potent, selective PDE1 inhibitor with IC50 of 11 nM, >24-fold selectivity over other PDEs, shows antifibrotic effects in vivo and in vitro. |
| PC-23407 |
Vardenafil
PDE5 inhibitor
|
Vardenafil is a potent, selective and orally active inhibitor of phosphodiesterase-5 (PDE5), inhibits the hydrolysis of cGMP by PDE5 with IC50 of 0.7 nM. |
| PC-23243 |
Senazodan hydrochloride
PDE3 inhibitor
|
Senazodan (MCI-154) hydrochloride is a small molecule Ca2+-sensitiser and PDE3 inhibitor, exerts positive inotropic and chronotropic effects by binding directly to troponin C. |
| PC-23242 |
Pimobendan
PDE3 inhibitor
|
Pimobendan (UD-CG115) is an oral Ca2+-sensitiser and PDE3 inhibitor (IC50=320 nM). |
| PC-22654 |
PDE4B/PDE5A inhibitor MDL3
PDE4B/PDE5A inhibitor
|
MDL3 is a potent, dual inhibitor of PDE4B and PDE5A, ameliorates pathophysiological signs and symptoms of liver injury and inflammation. |
