| Cat. No. |
Product Name |
Information |
| PC-62220 |
DNMDP
PDE3A inhibitor
|
DNMDP is a small molecule that induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12), specifically kills cancer cells with high levels of PDE3A and SLFN12 expression. |
| PC-62180 |
Eggmanone
PDE4 inhibitor
|
Eggmanone is a potent, selective inhibitor of PDE4 with (IC50=72 nM) that antagonizes the Hedgehog signaling pathway. |
| PC-62068 |
NCGC00071837
PDE4 inhibitor
|
NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11. |
| PC-61897 |
UK-369003
PDE5 inhibitor
|
UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6. |
| PC-61858 |
PF-03049423
PDE5 inhibitor
|
PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM. |
| PC-61617 |
GSK256066
PDE4 inhibitor
|
GSK256066 is a highly potent, selective PDE4B inhibitor with pIC50 of 11.1, apparent IC50 of 3.2 pM, inhibits PDE4 isoforms A-D with equal affinity. |
| PC-61387 |
Lotamilast
PDE4 inhibitor
|
Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM. |
| PC-61372 |
Difamilast
PDE4B inhibitor
|
Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). |
| PC-61348 |
PQ-10
PDE10A inhibitor
|
PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
| PC-61347 |
TC-E 5005
PDE10A inhibitor
|
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM. |
| PC-61346 |
BMS-843496
PDE10A inhibitor
|
BMS-843496 is a potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM. |
| PC-61345 |
ADT-094
PDE5/PDE10 inhibitor
|
ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively. |
