PDE4 activator MR-L2 | PDE4 activator | Probechem Biochemicals

Chemical Structure : PDE4 activator MR-L2

CAS No.: 2374703-19-0

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PDE4 activator MR-L2 (MR-L2)

货号: PC-73022Not For Human Use, Lab Use Only.

PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms.

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5 mg	￥2780	In stock
10 mg	￥4280	In stock
50 mg	￥9880	In stock
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生物&药学活性

PDE4 activator MR-L2 (MR-L2) is a small-molecule PDE4 activator, phenocopies PKA-mediated activation of long PDE4 isoforms.
MR-L2 reduces intracellular cAMP in MDCK cells without affecting PDE4 expression or cell viability.
MR-L2 suppresses the maximal cyst response elicited by both direct and indirect activation of adenylyl cyclase.
MR-L2 inhibits cyst formation in human models of ADPKD, also clearly suppresses the number of cysts formed in 3D culture in both unstimulated and vasopressin-treated (10 nM) cell cultures

物理化学性质&存储条件

分子量	441.712
分子式	C19H16Cl3FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(4-chloro-3-fluorophenyl)-5-ethyl-1H-1,2,4-triazol-1-yl)-N-(3,5-dichlorobenzyl)acetamide

参考文献

1. Omar F, et al. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329.

PDE4 activator MR-L2 (MR-L2)

生物&药学活性

物理化学性质&存储条件

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PDE4 activator MR-L2 (MR-L2)

生物&药学活性

物理化学性质&存储条件

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