STF-1084 | ENPP1 inhibitor | Probechem Biochemicals

Chemical Structure : STF-1084

CAS No.: 2298390-71-1

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STF-1084 (STF1084)

货号: PC-72236Not For Human Use, Lab Use Only.

STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.

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5 mg	￥3980	In stock
10 mg	￥5880	In stock
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生物&药学活性

STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM.
STF-1084 has low activity towards the closely related ectonucleotidases alkaline phosphatase (Ki,app>100 μM) and ENPP2 (Ki,app=5.5 μM), as well as against a panel of 468 kinases.
STF-1084 (10 uM) could completely block extracellular cGAMP degradation in ENPP1 overexpressing 293T cGAS cells, without effect on intracellular cGAMP.
STF-1084 rescued extracellular cGAMP levels in the media and induction of IFNB1 expression in CD14+ cells, wothout effect on cytokine production when cGAMP was electroporated into primary human PBMCs.

物理化学性质&存储条件

分子量	381.369
分子式	C17H24N3O5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid

参考文献

1. Jacqueline A Carozza, et al. Nat Cancer. 2020 Feb;1(2):184-196.

STF-1084 (STF1084)

生物&药学活性

物理化学性质&存储条件

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STF-1084 (STF1084)

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物理化学性质&存储条件

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