CPL500036 | PDE10A inhibitor | Probechem Biochemicals

Chemical Structure : CPL500036

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CPL500036 (CPL-500036)

货号: PC-72597Not For Human Use, Lab Use Only.

CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM.

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生物&药学活性

CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM.
CPL500036 is highly selective for PDE10A over other PDEs and common off-targets.
CPL500036 effectively penetrates the brain where increases cAMP/cGMP levels and phosphorylates effector proteins like AMPA subunits.
CPL500036 reduced sensorimotor deficits in 6-OHDA-lesioned rats.
Acute and chronic CPL500036 did not reduce effects of L-DOPA in sensorimotor tests.
Chronic CPL500036 treatment did not decrease L-DOPA-induced contralateral rotation.

物理化学性质&存储条件

分子量	341.378
分子式	C19H15N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,8-dimethyl-2-(2-phenylimidazo[1,2-a]pyrimidin-7-yl)-[1,2,4]triazolo[1,5-a]pyrazine

参考文献

1. Tomasz Lenda, et al. Eur J Pharmacol. 2021 Nov 5;910:174460.

2. Moszczyński-Pętkowski R, et al. Eur J Med Chem. 2018 Jul 15;155:96-116.

CPL500036 (CPL-500036)

生物&药学活性

物理化学性质&存储条件

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CPL500036 (CPL-500036)

生物&药学活性

物理化学性质&存储条件

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