Nauclefine

Chemical Structure : Nauclefine

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货号: PC-25665Not For Human Use, Lab Use Only.

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生物&药学活性

Nauclefine is an indole alkaloid natural productthat binds PDE3A but does not inhibit the PDE3A's phosphodiesterase activity, induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway.
Nauclefine could kill HeLa cells with an IC50 < 10 nM.
Nauclefine-induced cell death requires expression of PDE3A and SLFN12 in HeLa cells.
Nauclefine promotes interaction between PDE3A and SLFN12, which increased SLFN12 stability by preventing its fast decay.
Nauclefine causes cell death of the MCF7, EKVX, and H4 lines, and the cell death could be blocked by the noncytotoxic PDE3 inhibitors cilostazol and trequinsin.
Nauclefine significantly reduced overall growth of tumor in mice implanted with WT HeLa cells.

物理化学性质&存储条件

分子量	287.32
分子式	C18H13N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7,8-Dihydroindolo[2',3':3,4]pyrido[1,2-b][2,7]naphthyridin-5(13H)-one

参考文献

1. Ai Y, et al. Nat Commun. 2020 Jun 26;11(1):3236.

Nauclefine

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Nauclefine

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