PDE8A inhibitor 3a

Chemical Structure : PDE8A inhibitor 3a

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货号: PC-23487Not For Human Use, Lab Use Only.

PDE8A inhibitor 3a is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 10 nM, >220-fold selective over PDE1B, PDE3A, PDE5A1, PDE7A1, PDE9A2, and PDE11A4.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PDE8A inhibitor 3a is a potent, selective phosphodiesterase 8A (PDE8A) inhibitor with IC50 of 10 nM, >220-fold selective over PDE1B, PDE3A, PDE5A1, PDE7A1, PDE9A2, and PDE11A4.
PDE8A inhibitor 3a notably improved spatial learning and memory, increased the avoidance latency and decreased the error times in the UCCAO-treated mice.

物理化学性质&存储条件

分子量	354.75
分子式	C14H13ClF2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-chloro-9-(1-(4-(2,2-difluoroethoxy)pyridin-2-yl)ethyl)-9H-purin-6-amine

参考文献

1. Huang Y, et al. J Med Chem. 2020 Dec 24;63(24):15852-15863.