RF26 | PDE5 inhibitor | Probechem Biochemicals

Chemical Structure : RF26

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RF26 (Compound d12)

货号: PC-23406Not For Human Use, Lab Use Only.

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生物&药学活性

RF26 (Compound d12) is a highly potent and selective PDE5 inhibitor with IC50 of 1 nM, three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes.
RF26 has a mechanism of enzyme inhibition distinct from sildenafil.
RF26 is active against PDE5 catalytic domain (IC50=1 nM, full-length PDE5), but not PDE5 catalytic domain even at 1 uM.
RF26 inhibits PDE5 and increase the intracellular cGMP in live HEK-293 cells transfected to stably express a cGMP biosensor (EC50=6.7 uM).
RF26 improves memory impairment and ameliorates tau aggregation and neuroinflammation in the P301S tauopathy mouse model of Alzheimer's disease.

物理化学性质&存储条件

分子量	470.56
分子式	C26H32F2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(3-(tert-Butyl)-5-(3,5-difluoro-4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

参考文献

1. Sigler S, et al. Anticancer Agents Med Chem. 2024 Sep 2. doi: 10.2174/0118715206318802240821114353.

2. El-Desouky S, et al. Exp Neurol. 2024 Nov 14:115058.

3. Abdel-Halim M, et al. J Med Chem. 2021 Apr 22;64(8):4462-4477.

RF26 (Compound d12)

生物&药学活性

物理化学性质&存储条件

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RF26 (Compound d12)

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