VP3.15 dihydrobromide

Chemical Structure : VP3.15 dihydrobromide

CAS No.: 1281681-33-1

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货号: PC-23484Not For Human Use, Lab Use Only.

VP3.15 dihydrobromide is a potent, oral bioavailable and CNS penetrant dual PDE7/GSK-3 inhibitor with IC50 of 1.59 uM (PDE7) and 0.88 uM (GSK-3).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

VP3.15 dihydrobromide is a potent, oral bioavailable and CNS penetrant dual PDE7/GSK-3 inhibitor with IC50 of 1.59 uM (PDE7) and 0.88 uM (GSK-3).
VP3.15 increases intracellular cAMP levels in cells.
VP3.15 is efficacious in the amelioration of the clinical symptoms in EAE mice.
VP3.15 improves in vivo remyelination in mouse and increases both adult mouse and adult human oligodendrocyte progenitor cell (OPC) differentiation, in addition to its immune regulatory action.
VP3.15's dual inhibition is synergistic, as increasing intracellular levels of cAMP by cyclic nucleotide PDE inhibition both suppresses the immune response and increases remyelination, and in addition, inhibition of GSK3 limits experimental autoimmune encephalomyelitis in mice.

物理化学性质&存储条件

分子量	528.31
分子式	C20H24Br2N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Morpholinoethyl)-2,3-diphenyl-1,2,4-thiadiazol-5(2H)-imine dihydrobromide

参考文献

1. Martín-Álvarez R, et al. J Chem Neuroanat. 2017 Mar;80:27-36.

2. Medina-Rodríguez EM, et al. Sci Rep. 2017 Mar 3;7:43545.

3. Sánchez-Cruz A, et al. Mol Neurodegener. 2018 Apr 16;13(1):19.