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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Dipyridamole
Dipyridamole

Chemical Structure : Dipyridamole

CAS No.: 58-32-2

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Dipyridamole (DIPY)

货号: PC-23575Not For Human Use, Lab Use Only.

Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor, also is a potent inhibitor of ferroptosis in pulmonary epithelial and endothelial cells, binds to and activates superoxide dismutase 1 (SOD1).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor, also is a potent inhibitor of ferroptosis in pulmonary epithelial and endothelial cells, binds to and activates superoxide dismutase 1 (SOD1).
DIPY effectively mitigated ferroptosis and pulmonary damage in both mouse models and hAOs, primarily by downregulating heme oxygenase 1 (HMOX1).
DIPY binds to and activates superoxide dismutase 1 (SOD1), which in turn inhibits the CREB1/HMOX1 pathway, thereby suppressing ferroptosis.

物理化学性质&存储条件

分子量 504.64
分子式 C24H40N8O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetrakis(ethan-1-ol)

参考文献

1. Chen X, et al. Theranostics. 2024 Oct 21;14(18):6947-6968.

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