| Cat. No. |
Product Name |
Information |
| PC-27693 |
SMER3
SCFMet30 inhibitor
|
SMER3 is a specific small molecule inhibitor of E3 ubiquitin ligase SCFMet30, a member of SCF family E3 ubiquitin ligases. |
| PC-26969 |
D665-1412
RNF126 inhibitor
|
D665-1412 is a specific small-molecule inhibitor of E3 ligase RNF126, blocks hypoxia-induced pexophagy, stabilizes peroxisomes, normalizes lipid metabolism, and reactivates hepatocytic differentiation markers, thereby redifferentiating HCC cells and suppressing tumor progression in vitro and in vivo. |
| PC-26725 |
PELI1-IN-1
PELI1 inhibitor
|
PELI1-IN-1 (PELI1 inhibitor 3d) is a specific small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with binding Kd of 8.2 uM in fluorescence quenching assays, interrupts the interaction of PELI1 and SNAIL/SLUG. |
| PC-26546 |
FB231
Parkin activator
|
FB231 is a small molecule enhancer / activator of Parkin E3 ubiquitin ligase (PARK2) activity with EC50 of 6.75 uM in in vitro ubiquitination assay. |
| PC-26528 |
CLEO4-88
GID4 binder, ACAA1 inhibitor
|
CLEO4-88 is a molecular glue binder of CTLH E3 ligase substrate adaptor GID4 with KD of 5.6 uM, promotes GID4 interaction with the peroxisomal thiolase protein ACAA1 with EC50 of 12.5 nM in HTRF assays, inhibits the catalytic activity of ACAA1. |
| PC-26463 |
NX-1013
Cbl-b inhibitor
|
NX-1013 is a potent, specific inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) E3 ubiquitin ligase with binding Kd of 0.87 nM and 3.4 nM for CBL-B and CBL, and IC50 of 0.51 nM and 1.7 nM for CBLB and CBL. |
| PC-25921 |
XZA-1
HADH activator, CBX4 inhibitor
|
XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation. |
| PC-25638 |
XMU-MP-10 TFA salt
NEDD4 inhibitor
|
XMU-MP-10 TFA salt is a potent, specific, high-affinity inhibitor of HECT-type E3 ubiquitin ligase NEDD4 with MST KD of 43.92 nM, targets the HECT domain of NEDD4, significantly and selectively inhibits NEDD4 auto-ubiquitination. |
| PC-25637 |
XMU-MP-10
NEDD4 inhibitor
|
XMU-MP-10 is a potent, specific, high-affinity inhibitor of HECT-type E3 ubiquitin ligase NEDD4 with MST KD of 43.92 nM, targets the HECT domain of NEDD4, significantly and selectively inhibits NEDD4 auto-ubiquitination. |
| PC-25377 |
A5-MMC17
FBW7 modulator
|
A5-MMC17 is a specific, small molecule allosteric modulator of FBW7 E3 ligase with MST Kd of 45 uM, targets FBW7-pocket G, induces proteasome- and Cullin-RING-dependent c-MYC and c-JUN degradation in cells. |
| PC-24933 |
DDO-4033
SPOP inhibitor
|
DDO-4033 is a potent, selective E3 ligase speckle-type POZ protein (SPOP) inhibitor with IC50 of 16.48 uM, binds to SPOP-MATH with Kd of 15.1 uM in MST assay. |
| PC-24421 |
PRLX-93936
NPC molecular glue degrader
|
PRLX-93936 is a molecular glue that binds to and reprograms the TRIM21 ubiquitin ligase, causes TRIM21 to bind the nuclear pore protein NUP98, triggering nuclear pore complex (NPC) degradation. |
