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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-D665-1412
D665-1412

Chemical Structure : D665-1412

CAS No.:

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D665-1412

货号: PC-26969Not For Human Use, Lab Use Only.

D665-1412 is a specific small-molecule inhibitor of E3 ligase RNF126, blocks hypoxia-induced pexophagy, stabilizes peroxisomes, normalizes lipid metabolism, and reactivates hepatocytic differentiation markers, thereby redifferentiating HCC cells and suppressing tumor progression in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

D665-1412 is a specific small-molecule inhibitor of E3 ligase RNF126, blocks hypoxia-induced pexophagy, stabilizes peroxisomes, normalizes lipid metabolism, and reactivates hepatocytic differentiation markers, thereby redifferentiating HCC cells and suppressing tumor progression in vitro and in vivo.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Su Q, et al. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2535777123.

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