SMER3

Chemical Structure : SMER3

CAS No.: 67200-34-4

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货号: PC-27693Not For Human Use, Lab Use Only.

SMER3 is a specific small molecule inhibitor of E3 ubiquitin ligase SCFMet30, a member of SCF family E3 ubiquitin ligases.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
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生物&药学活性

SMER3 is a specific small molecule inhibitor of E3 ubiquitin ligase SCFMet30, a member of SCF family E3 ubiquitin ligases.
SMER3 does not inhibit the closely related SCFCdc4.
SMER3 enhances rapamycin's growth inhibitory effect by inhibition of SCFMet30.
SMER3 prevents the assembly of SCFMet30 or induces SCF complex dissociation.
SMER3 directly binds to Met30-Skp1, but not Skp1 alone.
SMER3 specifically inactivates SCFMet30 by binding to Met30.

物理化学性质&存储条件

分子量	224.18
分子式	C11H4N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

参考文献

1. Aghajan M, et al. Nat Biotechnol. 2010 Jul;28(7):738-42.

SMER3

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SMER3

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