| Cat. No. |
Product Name |
Information |
| PC-26824 |
DDB1 ligand-1
DDB1 ligand
|
DDB1 ligand-1 is a small molecule ligand of E3 ligase adapter protein DDB1 with TR-FRET IC50 of 26 nM, blocks the canonical DCAF/HBx peptide binding site of DDB1. |
| PC-26822 |
UBR2-IN-1
UBR2 inhibitor
|
UBR2-IN-1 is a selective, high-affinity peptidomimetic ligand / inhibitor of UBR box-containing ubiquitin E3 ligase UBR2. |
| PC-26774 |
SPOP-IN-1
SPOP inhibitor
|
SPOP-IN-1 (SPOP inhibitor 6lc) is a selective inhibitor of Speckle-type POZ protein (SPOP) E3 ubiquitin ligase, inhibits oncogenic SPOP-signaling pathway in ccRCC. |
| PC-26726 |
PELI1 inhibitor BZ61
PELI1 inhibitor
|
PELI1 inhibitor BZ61 is a small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with SPR Kd of 1.985 uM, suppresses the proliferation of both tyrosine kinase inhibitors (TKIs)-sensitive and TKI-resistant CML cells. |
| PC-26625 |
NSC689857
Skp2 inhibitor
|
NSC689857 is a potent EGFR and ubiquitin E3 ligase SCFSKP2 inhibitor with IC50 value of 36 uM for Skp2-Cks1 interaction, inhibit p27 ubiquitylation with IC50 of 30 uM. |
| PC-26049 |
GSR-3-120
c-Cbl inhibitor
|
GSR-3-120 (Compound 3-120) is a specific small molecule inhibitor / antagonist of E3 ubiquitin ligase c-Cbl, inhibits EGFR binding to CBL family proteins and competes with phosphotyrosine 1045 of the EGFR for binding to c-Cbl. |
| PC-25785 |
Cbl-b-IN-1
Cbl-b inhibitor
|
Cbl-b-IN-1 is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B) with IC50 of <100 nM, shows binding selectivity over C-CBL. |
| PC-25779 |
PF-G23
Cbl-b inhibitor
|
PF-G23 (CBL-B inhibitor G23) is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), shows binding selectivity over C-CBL. |
| PC-25778 |
HST-1011
Cbl-b inhibitor
|
HST-1011 is a potent, selective, orally bioavailable allosteric small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B), robustly increases anti-tumor immunity in vitro and in vivo. |
| PC-25777 |
Cbl-b inhibitor 10
Cbl-b inhibitor
|
Cbl-b inhibitor 10 is a potent and orally bioavailable Casitas B-lineage lymphoma-b (CBLB, Cbl-b) inhibitor with biochemical IC50 of 9.1 nM, and EC50 of 180.6 nM in IL-2 secretion assays. |
| PC-25478 |
Skp2-Cks1 inhibitor E35
Skp2 inhibitor
|
Skp2-Cks1 inhibitor E35 is a potent small molecule inhibitor of S-phase kinase-associated protein 2 (Skp2), inhbits Skp2-Cks1 protein-protein interaction (PPI) with IC50 of 4.86 uM. |
| PC-25147 |
OICR-41103
DCAF1 ligand
|
OICR-41103 is a potent, selective, and cell-active small molecule chemical probe for DCAF1 with SPR binding KD of 2 nM, targeting the DCAF1 WDR domain and displacing viral Vpr protein. |
