| Cat. No. |
Product Name |
Information |
| PC-27386 |
HPV E7-ZER1 inhibitor Compound 4
E7-ZER1 inhibitor
|
HPV E7-ZER1 inhibitor Compound 4 (ZER1-IN-1) is a first-in-class small-molecule inhibitor of ZER1 ARM-repeat domain, selectively blocks the ZER1-E7 interaction, leading to retinoblastoma (Rb) stabilization, inhibition of HPV-positive cervical cancer cell proliferation. |
| PC-27372 |
UFMylation inhibitor CP-24
DDRGK1-UFL1 inhibitor, UFMylation inhibitor
|
UFMylation inhibitor CP-24 is a potent, non-covalent UFMylation inhibitor targeting DDRGK1, disrupts of E3 ligase complex components DDRGK1-UFL1 interaction, binds directly to the DDRGK1 PCI domain, effectively inhibits UFMylation. |
| PC-27095 |
Cbl-b inhibitor 33
Cbl-b inhibitor
|
Cbl-b inhibitor 33 is a potent, selective, inactive-state inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (Cbl-b) with SPR Kd of 2.4 nM, has 14-fold selectivity over c-Cbl. |
| PC-26896 |
JWZ-8-103
NPC molecular glue degrader
|
JWZ-8-103 is a potent TRIM21-targeting molecular glue triggering nuclear pore complex (NPC) degradation, is 10-fold more potent than PRLX-93936 against parental PANC-1 (IC50=9.5 nM) and H661 cells overexpressing high levels of ectopic TRIM21 (IC50 <10 nM). |
| PC-26895 |
MAN-021
NPC molecular glue degrader
|
MAN-021 is a potent TRIM21-NUP98 molecular glue triggering nuclear pore complex (NPC) degradation, promotes TRIM21 to bind the nuclear pore protein NUP98, inhibits PANC-1 cell proliferation with EC50 of 1.9 nM. |
| PC-26824 |
DDB1 ligand-1
DDB1 ligand
|
DDB1 ligand-1 is a small molecule ligand of E3 ligase adapter protein DDB1 with TR-FRET IC50 of 26 nM, blocks the canonical DCAF/HBx peptide binding site of DDB1. |
| PC-26822 |
UBR2-IN-1
UBR2 inhibitor
|
UBR2-IN-1 is a selective, high-affinity peptidomimetic ligand / inhibitor of UBR box-containing ubiquitin E3 ligase UBR2. |
| PC-26774 |
SPOP-IN-1
SPOP inhibitor
|
SPOP-IN-1 (SPOP inhibitor 6lc) is a selective inhibitor of Speckle-type POZ protein (SPOP) E3 ubiquitin ligase, inhibits oncogenic SPOP-signaling pathway in ccRCC. |
| PC-26726 |
PELI1 inhibitor BZ61
PELI1 inhibitor
|
PELI1 inhibitor BZ61 is a small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with SPR Kd of 1.985 uM, suppresses the proliferation of both tyrosine kinase inhibitors (TKIs)-sensitive and TKI-resistant CML cells. |
| PC-26625 |
NSC689857
Skp2 inhibitor
|
NSC689857 is a potent EGFR and ubiquitin E3 ligase SCFSKP2 inhibitor with IC50 value of 36 uM for Skp2-Cks1 interaction, inhibit p27 ubiquitylation with IC50 of 30 uM. |
| PC-26049 |
GSR-3-120
c-Cbl inhibitor
|
GSR-3-120 (Compound 3-120) is a specific small molecule inhibitor / antagonist of E3 ubiquitin ligase c-Cbl, inhibits EGFR binding to CBL family proteins and competes with phosphotyrosine 1045 of the EGFR for binding to c-Cbl. |
| PC-25785 |
Cbl-b-IN-1
Cbl-b inhibitor
|
Cbl-b-IN-1 is a potent, selective, small molecule inhibitor of E3 ligase Casitas B-lineage lymphoma proto oncogene B (CBL-B) with IC50 of <100 nM, shows binding selectivity over C-CBL. |
