SPOP-IN-1 | SPOP inhibitor | Probechem Biochemicals

Chemical Structure : SPOP-IN-1

CAS No.: 2136270-56-7

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SPOP-IN-1 (SPOP inhibitor 6lc)

货号: PC-26774Not For Human Use, Lab Use Only.

SPOP-IN-1 (SPOP inhibitor 6lc) is a selective inhibitor of Speckle-type POZ protein (SPOP) E3 ubiquitin ligase, inhibits oncogenic SPOP-signaling pathway in ccRCC.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4780	In stock
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100 mg		Get quote

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生物&药学活性

SPOP-IN-1 (SPOP inhibitor 6lc) is a selective inhibitor of Speckle-type POZ protein (SPOP) E3 ubiquitin ligase, inhibits oncogenic SPOP-signaling pathway in ccRCC.
SPOP-IN-1 (SPOP inhibitor 6lc) suppresses the viability and inhibits the colony formation of ccRCC cell lines driven by cytoplasmic SPOP.
SPOP-IN-1 (SPOP inhibitor 6lc) binds to the SPOP protein in vitro and disrupts SPOP binding to phosphatase-and-tensin homologue (PTEN) in HEK293T cells.
SPOP-IN-1 (SPOP inhibitor 6lc) elevates levels of both PTEN and dual-specificity phosphatase 7 (DUSP7), and decreases levels of phosphorylated AKT and ERK in ccRCC cells.

物理化学性质&存储条件

分子量	505.64
分子式	C26H31N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Imino-10-methyl-N-(2-(4-methylpiperazin-1-yl)ethyl)-5-oxo-1-(2-(thiophen-2-yl)ethyl)-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide

参考文献

1. Dong Z, et al. J Med Chem. 2020 May 14;63(9):4849-4866.

SPOP-IN-1 (SPOP inhibitor 6lc)

生物&药学活性

物理化学性质&存储条件

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SPOP-IN-1 (SPOP inhibitor 6lc)

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