UFMylation inhibitor CP-24

Chemical Structure : UFMylation inhibitor CP-24

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货号: PC-27372Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UFMylation inhibitor CP-24 is a potent, non-covalent UFMylation inhibitor targeting DDRGK1, disrupts of E3 ligase complex components DDRGK1-UFL1 interaction, binds directly to the DDRGK1 PCI domain, effectively inhibits UFMylation.
CP-24 showed significant upregulation of ER stress-related genes compared to DMSO-treated U87 cells, including HSPA5, XBP1, ERN1, EIF2AK3, CANX, ATF4, and DDIT3.
CP-24 effectively reduces global UFMylation levels, decrease DDRGK1 protein levels, inhibits ER-phagy, and induce ER stress.
CP-24 impairs ER-phagy, induces ER stress, and exhibits robust anti-tumor effects in vitro and in multiple GBM mouse models.

物理化学性质&存储条件

分子量	423.53
分子式	C23H25N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(N,N-diethylsulfamoyl)-4-methylphenyl)-3-(quinolin-2-yl)acrylamide

参考文献

1. Tan P, et al. Signal Transduct Target Ther. 2026 Jul 20;11(1):281.