PELI1 inhibitor BZ61

Chemical Structure : PELI1 inhibitor BZ61

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货号: PC-26726Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PELI1 inhibitor BZ61 is a small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with SPR Kd of 1.985 uM, suppresses the proliferation of both tyrosine kinase inhibitors (TKIs)-sensitive and TKI-resistant CML cells.
BZ61 treatment markedly reduced the expression of both Snail and STAT3 in K562 cells, suppressed K63-linked ubiquitination of Snail and STAT3.
BZ61 inhibited K562 cells proliferation in a dose-dependent manner with IC50 of 13.6 uM.
BZ61 markedly reduced the interaction between PELI1 and BCR-ABL1 in Co-IP assays, induced a pronounced decrease in BCR-ABL1 protein levels but not mRNA levels.
BZ61 suppressed human CML burden and progression in vivo.

物理化学性质&存储条件

分子量	398.57
分子式	C23H30N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-4-((2-nonanamidophenyl)thio)benzamide

参考文献

1. Zhou Q, et al. Cell Death Dis. 2026 May 5. doi: 10.1038/s41419-026-08799-7.