| Cat. No. |
Product Name |
Information |
| PC-63514 |
BI8622
HUWE1 inhibitor
|
BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b). |
| PC-63321 |
BRD5529
CARD9-TRIM62 inhibitor
|
BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM. |
| PC-62453 |
Skp2 Inhibitor C1
Skp2 inhibitor
|
Skp2 inhibitor C1 (CKS1i) is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induces p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. |
| PC-62451 |
VHL-IN-15
VHL/HIF-1α inhibitor
|
VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.. |
| PC-62315 |
N-aryl benzimidazole
Rsp5/Nedd4 inhibitor
|
N-aryl benzimidazole (NAB) is a small molecule that strongly and selectively protects diverse cell types from α-syn toxicity, promotes endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4 in wild-type yeast cells. |
| PC-62313 |
Tasisulam
RBM39 degrader
|
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. |
| PC-62312 |
Tasisulam sodium
RBM39 degrader
|
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. |
| PC-61735 |
SPOP-IN-6b
SPOP inhibitor
|
SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP). |
| PC-61670 |
BC-1485
FIEL1 inhibitor
|
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination. |
| PC-61253 |
DT204
SCFSkp2 inhibitor
|
DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis. |
| PC-70324 |
Heclin
HECT ligase inhibitor
|
Heclin is a small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively. |
| PC-61192 |
SCF-I2
SCFCdc4 inhibitor
|
SCF-I2 is an allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assays. |
