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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-BC18630 free base
BC18630 free base

Chemical Structure : BC18630 free base

CAS No.: 2451935-95-6

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BC18630 free base (BC 18630)

货号: PC-49196Not For Human Use, Lab Use Only.

BC18630 free base (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BC18630 free base (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays.
    BC18630 decreases TFEB ubiquitination and significantly reduces the measured interaction between DCAF7 and TFEB in nucleus of cells.
    BC18630 attenuates a wide range of viral infections including SARS-CoV-2 infection, prevents virally-triggered TFEB degradation and dose-dependently reduces OC43 coronavirus infection, reduces HCoV-OC43 NP expression with IC50 of 0.3 uM.
    BC18630 (oral BID at 20mg/kg and 50 mg/kg for 5 days) dose-dependently reduced lung viral titer (PFU) in Syrian hamster model of SARS-CoV-2 infection, significantly reduced SARS-CoV-2 N-protein (NP) in lung, also reduced the observed level of lung injury, with the higher dose particularly reducing inflammatory infiltrates.

    物理化学性质&存储条件

    分子量 337.386
    分子式 C21H15N5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-1H-indol-5-yl-2-pyridin-4-ylquinazolin-4-amine

    参考文献

    1. Yuan Liu, et al. Res Sq. 2021 Apr 23;rs.3.rs-419305.

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